GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2129782 | 1 | rs61533446 | chr8:89455017 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs12761224 | 1 | rs61573157 | chr10:72520259 | TYSND1 | chr10:71897735-71906496:- | 0.21 | 3.4 | 0.000736 | Prion diseases |
| THCA | cis | rs12304921 | 1 | rs61577980 | chr12:51345370 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.7 | 3.46E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs61577980 | chr12:51345370 | TFCP2 | chr12:51488608-51566917:- | -0.19 | -4.08 | 5.23E-5 | Type 2 diabetes |
| THCA | cis | rs1027730 | 1 | rs61578106 | chr8:94070980 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.43 | 1.19E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6479891 | 1 | rs61579729 | chr10:65319313 | LOC84989 | chr10:65224989-65226320:+ | 0.25 | 3.84 | 0.000142 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61579729 | chr10:65319313 | NRBF2 | chr10:64893007-64914785:+ | 0.23 | 3.62 | 0.000322 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs7818688 | 1 | rs61596977 | chr8:95997165 | C8orf38 | chr8:95908040-96088396:+ | -0.28 | -4.52 | 7.88E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs726288 | 1 | rs61601271 | chr10:81727941 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs1768208 | 1 | rs616147 | chr3:39534481 | RPSA | chr3:39448204-39454030:+ | 0.21 | 5.27 | 2.06E-7 | Corticobasal degeneration;Progressive supranuclear palsy |
| THCA | cis | rs614226 | 1 | rs616157 | chr12:120925795 | POP5 | chr12:121016849-121019201:- | 0.14 | 4.1 | 4.9E-5 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs616157 | chr12:120925795 | RNF10 | chr12:120972132-121015396:+ | -0.21 | -3.35 | 0.000886 | Type 1 diabetes nephropathy |
| THCA | cis | rs8170 | 1 | rs61634114 | chr19:17387254 | ABHD8 | chr19:17402941-17414282:- | 0.26 | 4.2 | 3.14E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs61634114 | chr19:17387254 | ANKLE1 | chr19:17392454-17398454:+ | 0.28 | 4.69 | 3.51E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs61634114 | chr19:17387254 | OCEL1 | chr19:17337055-17340027:+ | 0.21 | 4.06 | 5.76E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |